DIABETIC NEUROPATHY
´Diabetic neuropathic pain is one of the biggest
complications of diabetes which has equal incidence in both type1 and type 2
diabetes.
´Neuropathic pain is one of the most frequent
complications (1.6% patients Worldwide).
´It can occur
as a co-morbidity of diseases like diabetes, side effects of treatment,
injury, chemotherapeutic drugs or as a
disease itself.
´DN
is clinical and sub clinical syndrome condition that accompanies diabetes with
the burning, tingling, prickly, and shooting pain in hands, feet, and legs.
´The
most studied mechanisms are
•increased
polyol pathway,
•activation
of PKC pathway,
•increased
oxidative stress,
•increased
Advanced Glycation Endproduct (AGE) formation and action
